Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, People's Republic of China; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, People's Republic of China. Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha, People's Republic of China. Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, People's Republic of China. Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany. Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, People's Republic of China; National Engineering and Research Center of Human Stem Cells, Changsha, People's Republic of China; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, People's Republic of China. Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, People's Republic of China; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, People's Republic of China; National Engineering and Research Center of Human Stem Cells, Changsha, People's Republic of China; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, People's Republic of China. Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha, People's Republic of China; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, People's Republic of China; Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany; Institute of Medical Diagnostics, Berlin, Germany. Electronic address: berthold.hocher@medma.uni-heidelberg.de.